"While the Renoir Crown rules the the Canopy Kingdom, the Medici rule its sizable underworld. On the surface, the wealthy Medici family is noble and generous, but beneath this facade lurks the truth: most everyone of power in New Meridian is being manipulated, coerced or directly controlled by the Medici crime family."
Filia is related to the Mafia by blood, according to Marie. Hints in the game suggest she is Lorenzo Medici's granddaughter or the daughter of one of the other mafia members.
Peacock and Marie's lives were changed by the Mafia. They are behind the slave traders of Rommelgrad who captured and mutilated Patricia. Marie would later find the Skull Heart, with which she wished to destroy the traders, thus becoming a Skullgirl.
Parasoul listed the Mafia as one of her dislikes. She is working hard to bring them to justice. As she gets ready to fight Cerebella, she says she has a message for her boss.
Ms. Fortune also listed the Mafia as one of her dislikes. Their hitwoman Black Dahlia sliced her and The Fishbone Gang into many pieces. But since she swallowed the Life Gem, Ms. Fortune didn't die and is now working to avenge her gang. When she defeats Cerebella she says her bosses are next.
- Although Marie states that Filia has a bloodline with Medici Mafia Riccardo but he does not recognize Filia at all. This is rather strange because Riccardo works with Medici Mafia and not knowing or recognizing Filia is rather incongruent. One theory is that Riccardo did not recognize her due to the fact Samson had changed Filia's hair color (which used to be blonde).
- In an image below there is woman who resembles Filia. This woman is possibly Filia's mother although it is not confirmed in game or by Lab Zero games and is just a speculation.
- The portrait depicting Lorenzo shows him in his youth, prior to his hair turning grey, whilst the portrait of Vitale depicts him older than he appears in the present.
- The name Medici is likely a reference to the Medici nobility family in Renaissance Italy. They were one of the most powerful and wealthy families in Europe, due to the many criminal groups under their control.