Grand Cathedral has two similar stage variations; 'Grand Cathedral' and 'Grand Cathedral (Empty)'. Both stages are unlocked by default for use in multiplayer and training.
The Grand Cathedral resembles a traditional Catholic church, with white marble walls, large stained glass windows and ornate frescoes. The frescoes, as well as an imposingly large statue in the background, are all in the likeness of Double's monster form.
The Grand Cathedral serves as a headquarters of sorts for Double, Valentine, and the Skullgirl herself. In several characters' story modes, Valentine and Double lure the unsuspecting into the confines of the cathedral in the hopes of finishing them off, or allowing the Skullgirl to do so.
The Grand Cathedral is ultimately destroyed in all story modes, and the Skullgirl's last stand takes place in its ruins.
- Prior to March 15, 2014, Grand Cathedral (Empty) was identical to its regular counterpart with the exception of having no background NPCs. This update considerably darkened the entire stage, with all colors drained from the stained glass windows.